Willison is a surname. Notable people with the surname include:

• Brian Willison (born 1977), American academic; former Executive Director of the Parsons Institute for Information Mapping
• David Willison (1919–2009), British soldier
• David Willison (pianist) (born 1936), English pianist
• George F. Willison (1896–1972), writer and editor who specialized in American history
• Herbert Willison (1872–1943), English solicitor and Liberal Party, later Liberal National politician
• Jackson Willison (born 1988 ), New Zealand rugby union footballer
• John Willison (1680–1750), Scottish clergyman
• John Stephen Willison (1856–1927), Canadian newspaperman, author, and businessman
• Kevin Willison (born 1958), Canadian professional ice hockey player
• Leigh Willison (born 1969), Australian rules football player
• Marjorie Willison, Canadian author of books on gardening and a radio personality
• Simon Willison, co-creator of the Django web framework
• Walter Willison (born 1947), American stage actor